POLISH RNA
BIOLOGY MEETING

28-30 September, 2023International Institute of Molecular and Cell Biology in Warsaw
The aim of the meeting is to explore RNA Biology and to inspire scientific community
to undertake new research directions in this rapidly growing field of life sciences.
The program will be broadly aligned with the RNA Biology in prokaryotic and eukaryotic systems.
The topics will include transcription, RNA processing and metabolism, non-coding RNAs, RNA in therapy and medicine.
Short talks and poster presentations will be selected from submitted abstracts.

See the video invitation

Great speakers      |      Recent discoveries      |      3 days of experience sharing

Meet The Speakers

Lori Passmore

MRC LMB
Laboratory of Molecular Biology
Cambridge, UK

Alfredo Castello

MRC CVR
University of Glasgow Centre for Virus Research
Glasgow, UK

Andrea Rentmeister

CiM
University of Münster, Cells in Motion Interfaculty Center Münster, Germany

Witold Filipowicz

FMI
Friedrich Miescher Institute for Biomedical Research
Basel, Switzerland

Magda Konarska

IMol
International Institute of Molecular Mechanisms and Machines PAS Warsaw, Poland

Program

  • Day 01

    28 September, 2023

  • Day 02

    29 September, 2023

  • Day 03

    30 September, 2023

08:00 - 09:00

Registration

09:00 - 09:15

Opening

09:15 - 10:00
Keynote Lecture
Chair: Andrzej Dziembowski, International Institute of Molecular and Cell Biology in Warsaw, Poland

Witold Filipowicz, FMI, Basel, Switzerland
Traversing the RNA world: lessons from the past and some ideas for the future
10:00 - 10:30

Coffee break

10:30 - 12:15

Session I
Chair: Dominika Nowis, Medical University of Warsaw, Poland

Bertrand Seraphin, Institute of Genetics, Molecular and Cellular Biology, France
HELZ2: a new, interferon-regulated, human 3’-5’ exoribonuclease of the RNB family is expressed from a non-canonical initiation codon

Paweł Sikorski, University of Warsaw, Poland
Modifications of mRNA 5ʹ-end defining transcripts as 'self' for innate immune system

Magdalena Wołczyk, International Institute of Molecular and Cell Biology in Warsaw, Poland
Sequence specificity of RIG-I/IFN signaling

Elżbieta Wanowska, Adam Mickiewicz University, Poznan, Poland
The role of OIP5-AS1 lncRNA in breast cancer

Aleksandra Brouze, International Institute of Molecular and Cell Biology in Warsaw, Poland
Immunoglobulin production is enhanced by cytoplasmic polyadenylation mediated by TENT5C acting in concert with FNDC3 proteins

Paweł Krawczyk, International Institute of Molecular and Cell Biology in Warsaw, Poland
SARS-CoV-2 mRNA vaccine is re-adenylated in vivo, enhancing antigen production and immune response

Maria Górna, University of Warsaw, Poland
Hold my cap(0): a 5' dependent mRNA capture method to analyze the yeast transcriptome

Renata Grzela, University of Warsaw, Poland
Crosstalk of cap structure modifications and innate immune response factors
12:15 - 13:45

Lunch

13:45 - 14:30

Keynote Lecture
Chair: Kinga Kamieniarz-Gdula, Adam Mickiewicz University, Poznan, Poland

Lori Passmore, MRC LMB, Cambridge, UK
Molecular machines that regulate mRNA poly(A) tails
14:30 - 16:15

Session II
Chair: Gracjan Michlewski, International Institute of Molecular and Cell Biology in Warsaw, Poland

Katarzyna Bandyra, University of Warsaw, Poland
Polynucleotide phosphorylase - an exoribonuclease and an RNA chaperone in one

Lidia Lipinska-Zubrycka, University of Warsaw, Poland
Dual role of uridylation in bulk mRNA Decay

Daria Riabov, Research Institute of Molecular Pathology, Austria
Structure of the recycling human U5 snRNP

Tomasz Turowski, Institute of Biochemistry and Biophysics PAS, Warsaw, Poland
Co-transcriptional adenylation of nascent RNA polymerase I transcripts

Łukasz Szewc, Adam Mickiewicz University, Poznan, Poland
The involvement of A. thaliana CFI polyadenylation factor in termination of transcription and U1 snRNP-dependent suppression of premature polyadenylation

Szymon Swiezewski, Institute of Biochemistry and Biophysics PAS, Warsaw, Poland
Promoter-pervasive transcription pausing Pol II to boost transcription

Michaela Ristová, University of Edinburgh, UK
A bridge through time: Pin4 links rapid post-transcriptional and transcriptional stress responses to maintain energy homeostasis in S. cerevisiae

Sebastian Sacharowski, Institute of Biochemistry and Biophysics PAS, Warsaw, Poland
Uridylation of lncRNAs enhances their chromatin tethering and ability to control seed dormancy through DOG1 gene activation

16:15 - 16:45

Coffee break

16:45 - 18:15

Session III
Chair: Magdalena Dziembowska, University of Warsaw, Poland

Agnieszka Fiszer, Institute of Bioorganic Chemistry PAS, Poznan, Poland
Separation of RNA- and protein-induced pathogenesis in novel Huntington’s disease mouse models

Anna Baud, Adam Mickiewicz University, Poznan, Poland
Identification of RNA binding proteins which influence translational efficiency of toxic polyglycine protein in fragile X-associated tremor/ataxia syndrome

Katarzyna Tutak, Adam Mickiewicz University, Poznan, Poland
RPS26 a novel RAN translation modifier of RNA harboring expanded CGG repeats in Fragile X-associated syndrome

Filip Stefaniak, International Institute of Molecular and Cell Biology in Warsaw, Poland
Structural Interaction Fingerprints for analysis of nucleic acid-ligand interactions

Tim Kolberg, Leipzig University, Germany
Led-Seq - ligation-enhanced double-end sequence-based structure analysis of RNA

Vladyslava Liudkovska, IMoL PAS, Warsaw, Poland
Dissecting the splicing landscape of human embryonic differentiation

18:15 - 19:45

Dinner

18:15 - 22:00

Poster Session I

08:45 - 09:15

Registration

09:15 - 10:00

Keynote Lecture
Chair: Sebastian Glatt, Malopolska Centre of Biotechnology, Jagiellonian University in Krakow, Poland

Alfredo Castello, MRC-University of Glasgow Centre for Virus Research, Glasgow, UK
When viral RNA met the cell: a story of protein-RNA interactions
10:00 - 10:30

Coffee break

10:30 - 12:15

Session IV
Chair: Michał Gdula, Adam Mickiewicz University, Poznan, Poland

Marta Sztachera, Institute of Bioorganic Chemistry PAS, Poznan, Poland
Investigation of RNA-protein interactions and brain-specific RBPome in the mouse brain tissue

Mikołaj Olejniczak, Adam Mickiewicz University, Poznan, Poland
RNA recognition by FinO-domain proteins

Rafał Mańka, University of Opole, Poland
A study of the RNA interactions with membrane vesicles

Kishor Gawade, Adam Mickiewicz University, Poznan, Poland
FUS modulates the level of ribosomal RNA modifications in health and disease

Mateusz Bajczyk, Adam Mickiewicz University, Poznan, Poland
The cross-talk between PCF11-similar proteins and CstF64 in flower development in Arabidopsis thaliana

Ewa Anna Grzybowska, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland
The spectrum of RNA targets of intrinsically disordered HAX1 protein indicates predominant binding to coding regions and points to the role in ribosome biogenesis and translation

Joanna Krupka, University of Cambridge, UK
In search of lost ORFs: ultra-sensitive map of noncanonical Open Reading Frames essential for lymphoid cells

12:15 - 13:45

Lunch

13:45 - 14:30

Keynote Lecture
Chair: Elżbieta Kierzek, Institute of Bioorganic Chemistry PAS, Poznan, Poland

Magda Konarska, IMol PAS, Warsaw, Poland
Dynamic changes within the RNA catalytic core leading to the second step of splicing
14:30 - 16:15

Session V
Chair: Marcin Nowotny, International Institute of Molecular and Cell Biology in Warsaw, Poland

Maja Cieplak-Rotowska, IMol PAS, Warsaw, Poland
Cwc25’s role in choosing the right adenosine as the branch site during the first step of splicing

Ishani, IMol PAS, Warsaw, Poland
Introns defective for the second step of splicing accumulate in the first step spliceosomal conformation, generating dysfunctional, jammed spliceosomes

Olga Gewartowska, International Institute of Molecular and Cell Biology in Warsaw, Poland
dTag system allows for in vivo studies of essential genes involved RNA metabolism

Monika Kwiatkowska, Institute of Bioorganic Chemistry PAS, Poznan, Poland
Making zebrafish the dark horse in long noncoding RNA research

Klaudia Skrzypek, Jagiellonian University Medical College, Krakow, Poland
Potential of SNAIL-dependent small RNAs as regulatory molecules in rhabdomyosarcoma progression

Przemysław Płociński, University of Łódź, Poland
Bacterial PNPase as a candidate for antimicrobial drug discovery

Mario Mörl, Leipzig University, Germany
Living in the past: reconstruction of an ancestral tRNA nucleotidyltransferase candidate

Agnieszka Kiliszek, Institute of Bioorganic Chemistry PAS, Poznan, Poland
Structural studies of small ligands targeting disease-related RNA molecules

16:15 - 16:45

Coffee break

16:45 - 18:15

Session VI
Chair: Marta Koblowska, University of Warsaw, Poland

Leszek Błaszczyk, Institute of Bioorganic Chemistry PAS, Poznan,
Poland Exploring long-range RNA interaction in p53 mRNA

Kaspar Burger, University Hospital Würzburg & University of Würzburg, Germany
NONO nucleolar re-localisation promotes genome stability by shielding nascent transcripts from DNA double-strand breaks

Monika Jóźwiak, Adam Mickiewicz University, Poznan, Poland
The role of DRH1, RH46 and RH40 in miRNA biogenesis in Arabidopsis thaliana

Ewa Stępniak-Konieczna, Adam Mickiewicz University, Poznan, Poland
Therapeutic modulation of MBNL1 splicing factor in myotonic dystrophy

Agata Stępień, Adam Mickiewicz University, Poznan, Poland
Transcription termination in carcinogenesis

Monika Zakrzewska-Płaczek, University of Warsaw, Poland
Arabidopsis DXO1 affects the processing of precursors of cytoplasmic and chloroplast ribosomal RNA

Piotr Gerlach, IMoL PAS, Warsaw, Poland
Bunyaviral strategies to reorganize and exploit cellular translation

18:15 - 19:45

Dinner

18:15 - 22:00

Poster Session II

08:45 - 09:15

Registration

09:15 - 10:00

Keynote Lecture
Chair: Jacek Jemielity, University of Warsaw, Poland

Andrea Rentmeister, Institute of Biochemistry, Department of Chemistry and Pharmacy, University of Münster, Germany
Optochemical control of mRNA translation
10:00 - 10:15

Sponsor talk
Chiara Reggio, Scale Bioscience / Altium
Single Cell RNAseq at SCALE: Unlock single-cell gene expression for every researcher and experiment with ScaleBio
10:15 - 10:45

Coffee break

10:45 - 12:00

Session VII
Chair: Agata Starosta, Institute of Biochemistry and Biophysics PAS, Warsaw, Poland

Guillem Ylla, Jagiellonian University, Krakow, Poland
The transcriptomics of the evolution of insect metamorphosis

Dilek Cansu Gurer, Izmir Institute of Technology, Turkey
Genome-wide identification and classification of sisRNAs in human cells

Rahul Mehta, Malopolska Centre of Biotechnology, Jagiellonian University, Poland
Structural and biophysical characterization of non-coding RNAs

Tales Rocha de Moura, International Institute of Molecular and Cell Biology in Warsaw, Poland
Structural studies of the Betacoronaviruses 5′-proximal regions

Małgorzata Sierant, Centre of Molecular and Macromolecular Studies PAS, Lodz, Poland
Intracellular damage of mcm5S2U-tRNA induced by oxidative stress

Oleg Dmytrenko, Helmholtz Institute for RNA-based Infection Research, Germany
Cas12a2 nucleases form three functionally-distinct clades
12:00 - 12:15

Awards & closing ceremony

POLISH RNA BIOLOGY MEETING 2023 - Abstract Book

The conference Polish RNA Biology Meeting is supported by the funds from EU H2020 ERA Chairs MOSaIC Project

Accommodation

Conference participants are encouraged to make their own hotel bookings - we do not offer room reservations via the conference website.

ibis Warszawa Reduta

Bitwy Warszawskiej 16
02-366 Warsaw

Distance from Venue: 1.6 KM

Distance from City Centre: 4.0 KM

Distance from railway stations:
- Central Railway Station (Warszawa Centralna): 3.0 KM
- West Railway Station (Warszawa Zachodnia): 1.0 KM

Distance from Warsaw Chopin Airport: 7.0 KM

Room price (PLN): -10% from the prices valid on the day of sending the inquiry

To book a room please send an e-mail to: H7125-RE@ACCOR.COM and H7125-FO4@ACCOR.COM and use the password: PL-RNA.
Reservations will be confirmed upon availability.

ibis Warszawa Stare Miasto (Old Town)

Muranowska 2
00-209 Warsaw

Distance from Venue: 8.0 KM

Distance from City Centre: 3.0 KM

Distance from railway stations:
- Central Railway Station (Warszawa Centralna): 3.0 KM
- West Railway Station (Warszawa Zachodnia): 9.0 KM

Distance from Warsaw Chopin Airport: 15.0 KM

Room price: SINGLE: 400 PLN | TWIN: 430 PLN

To book a room please complete the form and send it to email: H3714-RE@ACCOR.COM (use the password: PL-RNA). The special price will be offer up to 27.07.2023.

Novotel Warszawa Centrum

Marszałkowska 94
00-510 Warsaw

Distance from Venue: 4.6 KM

Distance from City Centre: situated in the heart of the city

Distance from railway stations:
- Central Railway Station (Warszawa Centralna): 0.5 KM
- West Railway Station (Warszawa Zachodnia): 4.0 KM

Distance from Warsaw Chopin Airport: 9.0 KM

Room price: SINGLE: 603,72 PLN | TWIN: 646,92 PLN

To book a room please complete the form and send it to email: H3383-RE5@accor.com and use the password: PL-RNA. Reservations will be confirmed upon availability. The special price will be offer up to 28.02.2023.

Radisson Collection Hotel, Warsaw*****

Grzybowska 24
00-132 Warsaw

Distance from Venue: 6.0 KM

Distance from City Centre: 1.0 KM

Distance from railway stations:
- Central Railway Station (Warszawa Centralna): 1.5 KM
- West Railway Station (Warszawa Zachodnia): 3.6 KM

Distance from Warsaw Chopin Airport: 10.0 KM

Room price: SINGLE: 750 PLN

To book a room please use link and use the password: PL-RNA. Reservations will be confirmed upon availability.


IBIB PAN Conference Center

Księcia Trojdena 4
02-109 Warsaw

Distance from Venue: in the same building

Distance from City Centre: 5.0 KM

Distance from railway stations:
- Central Railway Station (Warszawa Centralna): 5.0 KM
- West Railway Station (Warszawa Zachodnia): 3.0 KM

Distance from Warsaw Chopin Airport: 5.0 KM

Room price (PLN): -10% from the prices valid on the day of sending the inquiry

To book a room please send an e-mail to: konferencje@ibib.waw.pl and use the password: PL-RNA. The special price will be offer up to 07.09.2023.

Sound Garden Hotel

Żwirki i Wigury 18
02-092 Warsaw

Distance from Venue: 2.0 KM

Distance from City Centre: 6.0 KM

Distance from railway stations:
- Central Railway Station (Warszawa Centralna): 5.0 KM
- West Railway Station (Warszawa Zachodnia): 6.0 KM

Distance from Warsaw Chopin Airport: 3.5 KM

Room price: SINGLE: 390 PLN

To book a room please use link and use the password: PL-RNA. Reservations will be confirmed upon availability.

Novotel Warszawa Airport

1 sierpnia 1
02-134 Warsaw

Distance from Venue: 2.2 KM

Distance from City Centre: 5.0 KM

Distance from railway stations:
- Central Railway Station (Warszawa Centralna): 5.0 KM
- West Railway Station (Warszawa Zachodnia): 4.0 KM

Distance from Warsaw Chopin Airport: 3.0 KM

Room price: SINGLE: 380 PLN | TWIN: 430 PLN

To book a room please send an e-mail to: H0527-RE@ACCOR.COM and use the password: PL-RNA. Reservations will be confirmed upon availability.

Airport Hotel Okęcie****

Komitetu Obrony Robotników 24
02-148 Warsaw

Distance from Venue: 4.0 KM

Distance from City Centre: 7.5 KM

Distance from railway stations:
- Central Railway Station (Warszawa Centralna): 7.4 KM
- West Railway Station (Warszawa Zachodnia): 9.0 KM

Distance from Warsaw Chopin Airport: 3.0 KM

Room price (PLN): -15% from the prices valid on the day of sending the inquiry

To book a room please send an e-mail to: rezerwacja@airporthotel.pl and use the password: PL-RNA. Reservations will be confirmed upon availability.

Radisson Blu Sobieski Hotel, Warsaw

plac Artura Zawiszy 1
02-025 Warsaw

Distance from Venue: 3.2 KM

Distance from City Centre: 1.5 KM

Distance from railway stations:
- Central Railway Station (Warszawa Centralna): 1.5 KM
- West Railway Station (Warszawa Zachodnia): 3.0 KM

Distance from Warsaw Chopin Airport: 7.0 KM

Room price (PLN): -20% from the prices valid on the day of sending the inquiry

To book a room please send an e-mail to: reservation.sobieski.warsaw@radissonblu.com and use the password:
PL-RNA. Reservations will be confirmed upon availability.

Scientific Committee

Gracjan Michlewski - Chair, IIMCB, Warsaw, Poland and University of Edinburgh, UK

Sebastian Glatt, Malopolska Centre of Biotechnology, Jagiellonian University in Krakow, Poland

Jacek Jemielity, University of Warsaw, Poland

Kinga Kamieniarz-Gdula, Adam Mickiewicz University, Poznan, Poland

Elzbieta Kierzek, Institute of Bioorganic Chemistry, PAS, Poznan, Poland

Joanna Kufel, University of Warsaw, Poland

IIMCB Organizing Committee

Andrzej Dziembowski - Chair

Urszula Białek-Wyrzykowska

Kamila Gajdek

Daria Goś

Dorota Libiszowska

Marcin Ogonowski

Iwona Pilecka

Agnieszka Potęga

Eliza Ratkowska

Jakub Skaruz

Agata Szulim

Agnieszka Wilamowska

Organizer

International Institute of Molecular and Cell Biology in Warsaw
4 Ks. Trojdena Street
02-109 Warsaw, Poland

Venue

IBIB Conference Center
4 Ks. Trojdena Street
02-109 Warsaw, Poland

Call Us

+48 22 597 07 00

Email Us

pl-rna@iimcb.gov.pl